I got some tissues for your issues tell 'em blow this
One would normally wipe there nose/eyes of tears with a tissue when a sort of problem (issue) happens. You would also blow your nose into a tissue.
In this case his penis is a tissue and the other people are issues, and instead of blowing into a tissue, you would blow Rocky’s penis.
To help improve the meaning of these lyrics, visit “Tim Westwood Freestyle” by A$AP Rocky Lyrics and leave a comment on the lyrics box