Listen to that Duquesne whistle blowing
Blowing like it's gonna sweep my world away
from Bob Dylan – Duquesne Whistle Lyrics on Rap Genius
Meaning
Duquesne whistle was the name of the largest blast furnace in the world, named the “Dorothy Six”, built in Duquesne, PA:

Additionally, the Duquesne line train between New York and Pittsburgh. Amtrak’s Keystone was a train service between New York Penn Station and Pittsburgh Penn Station. That route is now served by the Pennsylvanian. Prior to Amtrak the route was known as the Duquesne, named after Fort Duquesne in Pittsburgh, and was operated by the Pennsylvania Railroad.
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