Mami we run the town, stay away if you 300 pounds

from 50 Cent (Ft. G-Unit) – Fat Bitch Lyrics on Rap Genius

Meaning

If you want to get involved with anyone from G-Unit, with exception of Yayo, you betta be a nice bitch because they don’t like fat bitches, and as they are on the top of the game they can get any bitch that they want easily.

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