And you know what they say
When you're great it's not murder it's assassinate
So assassinate me, bitch

from Lil Wayne – Playing With Fire Lyrics on Rap Genius

Meaning

If you’re great in the eyes of the public (Like historic figures such as John F. Kennedy, Abraham Lincoln and Martin Luther King, JR), if you get murdered, there’s always one term the media loves to use: assassination.

Lil Wayne, at this point of his career, was also held in high regards when it came to hip-hop, possibly rivaling the before mentioned The Notorious B.I.G, who infamously started the saying “You’re nobody till somebody kills you”, in his song of the same name.

Since he’s so great at this time, he feels like somebody is going to assassinate him so they can get famous, and boldly dares them to try to do so.

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