The last to reach my high od'd on Vicodin

from Alex Ruffin (Ft. Deondre Jones) – Fisticuff (Prod. Nonsense Beats) Lyrics on Rap Genius

Meaning

A pain reliever, commonly used as a method to get high, famously used by Eminem on his 20-pill-a-day addiction.

Here’s a ridiculous amount of Vicodin references in at least 8 of Eminem’s songs.

Argue with your wife again, she found Vicodin
Vain Vicodin, vrin vrin vrin!
Vicodin’s like a nitrogen hydrogen vitamin
And dropped 2 extra straight rocks and Vicodin out my pocket they cost less
Frightened with five little white Vicodin pills bitin' him
Now I’m popping Vics, Percs and Methadone pills
Say goodbye, here I am again, naked wives and Vicodin
So I take a Vicodin, splash it hits my stomach then, ahhhh

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