Ya'll niggas better sober up before ya'll speak to me, don't come at me high

from 50 Cent (Ft. Bravehearts & Nas) – Who U Rep With Lyrics on Rap Genius

Meaning

50 Cent want you to be sober when you speak to him, he wants to see your true colors, your honesty.

You cannot talk business when you are high or drunk, you might end up saying things you don’t mean

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