Wake up screamin' in my sleep

from 2Pac (Ft. Outlawz) – Fuck Em All Lyrics on Rap Genius

Meaning
  1. It is a run-on from the previous bar, since he was seeing visions, this bar implies he is going crazy, and is waking up screaming from his dreams.

  2. This is from a scene where he is in prison, and he wakes up while being attacked

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