Ghettos, America. U.S. to the izzay
Killa in the citywide sprizzay

from Lupe Fiasco – Audubon Ballroom Lyrics on Rap Genius

Meaning

From the United States of American to Israel, there exists mass sections within the populace of ethnic and regional minorities, an underclass of impoverished workers, or a diaspora of political refugees.

A self-conscious use of “izzle language” by Lupe. See this note for the history of this slang

Possibly, specifically, a reference to Jay-Z’s “Izzo (H.O.V.A.)”

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