Hatin’ on your happiness you hit ‘em off with laughs
Smile ‘til they surrender, then you kill ‘em off with glad
Lupe is saying that for people who try to bring you down, kill them with kindness. He also plays off the Glad commercials, “Don’t get sad, get Glad” and then continues to play off killing people with kindness as in smiling and act like you’re glad.
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