I don't know what really matters anymore
Cause I don't know what really matters anymore

from Lupe Fiasco (Ft. Casey Benjamin) – Strange Fruition Lyrics on Rap Genius

Meaning

Lupe is getting frustrated with the way things are going in society.

A couple things to recognize:
-The slowed down, distorted sound the lyrics get delivered, emphasizing the slow decay of his mentality and the world around him.
-He repeats, “I don’t know what really matters anymore”, which may refer to the wicked problems that don’t get solved and continue to stay prevalent.

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