Synthetic heroin

from Macklemore and Ryan Lewis (Ft. Evan Roman & Macklemore) – A Wake Lyrics on Rap Genius

Meaning

Synthetic herion is created in a laboratory setting, is a less addicting derivative of opium, and usually used for detoxification or pain.

Macklemore is probably referencing Oxycontin or Suboxen, which are two very prevalent drugs in his hometown of Seattle.

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