I've seen oxycontin take 3 lives

from Macklemore and Ryan Lewis (Ft. Fences) – Otherside Remix Lyrics on Rap Genius

Meaning

Macklemore is referring to friends of his whom he has seen die from overdosing on Oxycontin. The number has since increased to 4, and he has changed the lyrics for the song’s live performances.

To help improve the meaning of these lyrics, visit "Otherside Remix" by Macklemore and Ryan Lewis (Ft. Fences) Lyrics and leave a comment on the lyrics box