Game of cat and mouse turns sickly and nasty
When these Tom and Jerries turn to itchy and scratchies

from ForestPunk – L.A Skylights Lyrics on Rap Genius

Meaning

When you are playing a “game of cat and mouse” its you and whoever your opponent or adversary is bouncing between hunter and hunted. In this case its competing with other artists to “make it” in a city saturated with talent and wannabes, Los Angeles. It turns from friendly competition to cutthroat battle royale when the stakes seemingly get raised. that is symbolised by “Tom and Jerries” the famous cartoon of the cat tom endlessly chasing the mouse Jerry.
https://www.youtube.com/watch?v=fCNvfWhB9NE It is a pretty light and funny cartoon…on the other hand, Itchy and Scratchy is the Simpsons famous parody OF tom and jerry, except made UBER violent and quite morbid. So by saying Tom and Jerry turn to Itchy and Scratchy…shit goes from nice to not so nice.
https://www.youtube.com/watch?v=ZWy_7eHBLRE

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