Proactive rap, you know they put drug in the cream
Proactiv —> an acne medication of dubious value, endorsed by celebrities like Diddy and Jessica Simpsons
Cream —> C.R.E.A.M., Wu slang for money
So by “putting drug in the cream”, GZA could be referring to 50 as a sell out, and that he’s now addicted to acting like a steppin fetcher.
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