We put our glass to the sky and lift up
And live tonight cause you can't take it with ya
So raise a pint for the people that aren't with us
And live tonight cause you can't take it with ya

from Macklemore and Ryan Lewis – Irish Celebration Lyrics on Rap Genius

Meaning

Have a great time tonight for all of Ireland, the ones that fought for you. Also, because you have to make the most out of your life.

Mackelmore isn’t actually from Ireland but he feels a connection because of his heritage. That’s why he raises his glass for his ancestors who “aren’t with us”.

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