But you're the only one cause I don't trust these bitches
I don't trust these bitches,

from Drake (Ft. The Weeknd) – Trust Issues (Gizzle Remix) Lyrics on Rap Genius

Meaning

He’s saying that he doesn’t trust anyone else to mix his drink. The drink entails the use of drugs (promethazine and codeine), so he obviously needs someone he trusts to mix his drink.
After all, he could turn his back once and something else could be slipped in his drink, hence… the next line: “they might catch me slippin'”

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