No pill can heal the ill of this
This line sounds a little more like a reference to HIV than anything else. There is no known cure for it, so once you have it it isn’t like you can take a pill and be cured.
But it also could be talking about how the chaotic effects that the Streets and/or the government create can’t simply be solved by talking a pill.
A possible Matrix reference, to the famous scene where Neo is offered either a red or blue pill. The red one will bring him back into the “real world”, but that isn’t an option here. Once you let the world to become like this, there’s no going back.
Also the pill in this case could be a reference to birth control. Sure, a pill can effectively stop pregnancy, but that isn’t the ill Lupe is talking about. He is concerned with how these young girls are having sex without thinking because they know they can just take a pill. This stops the pregnancy but ruins their culture.
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