So you never know, never never know
Never know enough, 'til it's over love
'Til we lose control, SYSTEM OVERLOAD
Screaming, "No, no, no, n-nooo!"

from Kanye West – Love Lockdown Lyrics on Rap Genius

Meaning

You never really know enough about a situation until it’s over, and sometimes you’ll regret it and end up saying “no, no, no, no.” Kanye is upset because of his decision to leave the girl he thought he loved, and he’s unsure if leaving her was the right decision or not.

Kanye added a distortion effect over the “System overload” part to paint an entire picture with those words

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