It's a dirty game, is any man worthy of fame?
Dirty game refers what you dont know what goes on behind the scene. Nas is saying that life is a dangerous and dirty game and the moves that are played are not clean. Since the moves are not clean and morally objectionable, does any man who plays and wins deserve anything? Notice how artists such as Drake or 2chainz are selling millions while potent rappers who speak about true shit aren’t known. Being at the top is flawed like the system.
This is called selling your soul:
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