Of the fools that are used as instruments in the game
This can be interpreted as another reference back to his epic, The Cool where it speaks of the hustlers really just being suckered by the character, The Game into believing that bad is good.
Another take on the meaning is that superficial rappers reign in the rap game because of their popularity. But these same rappers are fools because they don’t understand how their music keeps the listeners oppressed in their own ignorance.
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