Oh yeah, Mobb Deep: you wanna fuck with us?
You little young-ass motherfuckers
Don't one of you niggas got sickle-cell or something?
You're fucking with me, nigga
You fuck around and catch a seizure or a heart-attack

from 2Pac (Ft. Outlawz) – Hit 'Em Up Lyrics on Rap Genius

2Pac uses the outro to fire shots at several other people he’s beefing with, including New York duo Mobb Deep. Mobb Deep had taken part in the East/West coast beef by releasing “L.A L.A”. Reportedly 2pac felt the song dissed him. Mobb Deep would reply to Hit'Em Up with classic diss track Drop A Gem On ‘Em

Many people at the time thought 2pac took it too far by referencing the fact that Prodigy (one half of Mobb Deep) suffers from sickle-cell anemia. Prodigy made a memorable track about his sickness called “You Can Never Feel My Pain” on his first solo album

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