Nigga that thought I wasn't holdin a gun
And tried to ride up on me like Afeni Shakur's only son

from Game – No More Fun and Games Lyrics 1 on Rap Genius

Afeni Shakur’s only son is 2pac, who was murdered when a car rolled up alongside his and fired upon him. They tried to do in Game just like Pac, but he was armed and defended himself.

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