Come alive, hoes, like a litter full of puppies
Or a baby with a onesie on,

from Big Boi (Ft. Sleepy Brown) – The Thickets Lyrics on Rap Genius

Meaning

A litter of puppies is a group of newborn baby dogs, so they just came alive, similar to a newborn baby. Big Boi wants fans to wake up from the brainwash the radio has them under.

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