Well you got a problem on your hands that you can't deal with
Meek was disrespecting Cassidy — Tha Problem and now he has got himself a problem on his hands he can’t deal with.
Cassidy has a Split Personality. He is either Cassidy Tha Problem, or he’s Cassidy Tha Hustla. In this intro, he refer to himself as Tha Problem.
A clever metaphor also sees light here, Cassidy says: “you got a problem on your hands that you can’t deal with” — Thus is an allusion to a card game where you can find yourself having a card on your hands that wont help you winning, hence “can’t deal with”.
Cassidy is that card — Meek is not winning.
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