And that’s, B’s up, hoes down

from Game (Ft. Lil Wayne) – Red Nation Lyrics on Rap Genius

Meaning

He holds his Bloods gang members in higher esteem than women (how does Ms. Cita feel about this line?)

This can also mean putting “B’s up” with your hands for the “blood” symbol, and “hoes down” means girls get down on their knees, if you know what I mean.

This is also a reference to Snoop Dogg’s, “G’s Up, Hoes Down”(which is odd, because Snoop is a Crip). Here’s a better explanation of this connection.

This also references to the line before it, “I can’t tell you whats good, but I can tell you whats what”

Whats good — Hoes
Whats up? — B’s up.

Bloods before hoes.

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