Cause my diesel will make fiends do the up-town shake

from 50 Cent (Ft. Lloyd Banks & Tony Yayo) – That's What's Up Lyrics on Rap Genius

Diesel is slang for heroin, because heroine can also be called black tar.

The up-town shake is referencing dancing, but 50 is saying that his drugs are so good that fiends will be hooked so quick that they’ll be shaking, like they’re dancing, cause they need more.

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