But you gotta understand, our differences is the same
What starts in clouded minds, finishes in the reign

from Lupe Fiasco – Glory Lyrics on Rap Genius

Meaning

Despite being a different race, religion, etc from one another, we are all the same. Clouded minds refer to ignorance. By being ignorant it causes the rule of ignorant people by tyranny (who reign over them). He goes into this analogy early by describing the king as oppression and the queen as ignorance.

Note the wordplay: “clouded mind” / “rain/reign”

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