Don't let the juice spill Pac!
This line is referring to Juice, the 1992 movie with 2Pac. In the movie he goes crazy because of the power he feels he has after killing a couple people, but in the end, he died which is the juice being spilled. So the line itself is saying don’t let the power go to your head. Chance already stated earlier in the verse he was a humble dude, so no worries.
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