Everytime I look up, it's another red cup
Bunch of niggas in the game but they ain't playing with us

from Wiz Khalifa – No Sleep Lyrics on Rap Genius

Meaning

“Game” both in the figurative sense (the “Rap Game”) and the puerile frat-boy pastime of “beer pong” aka “Beirut”

(note the trademark red cups)

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