Top down, it’s upset

from Lil Wayne (Ft. Rick Ross) – John Lyrics on Rap Genius

Meaning

The roof of his car is down. Down can also mean upset in a different context

Essentially, Weezy “turns that frown upside down” by taking the top off his convertible

This line can also be an extension of the sports metaphor earlier, saying that the top dog has been defeated by someone lower. In sports, this is called an upset if a weaker opponent defeats a stronger opponent.

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