Build with the gods and double knowledge of self

from 50 Cent (Ft. Kendrick Lamar & Kidd Kidd) – We Up Lyrics 1 on Rap Genius

Meaning

50 is down with hip-hop’s number religion, the 5% Nation of Islam, who refer to their male members as “gods”

Double knowledge of self = two sides to yourself, good/bad, that one must explore (Yin and Yang). This is an idea that Fif previously dealt with in “I’m Supposed to Die Tonight”:

Sometimes I sit and look at life from a different angle
Don’t know if I’m God’s child or I’m Satan’s angel

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