While the definition of “Uptown” in an N.O. context is somewhat fungible, the world’s most reliable encyclopedia explains what Gregory means here:
While some may quibble about the exact boundaries, “Uptown” generally refers to the areas of the city closer to the River (riverside of S. Claiborne Avenue) upriver from the Pontchartrain Expressway and modern CBD/Warehouse District neighborhood.
Unlike many parts of N.O., Uptown has had racially and ethnically mixed areas since the 19th century. The area includes Tulane University, pictured below:
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