I'm taking wages down in Vegas just in case Tyson
Have a major night off

from Jay-Z – Politics As Usual Lyrics on Rap Genius

Actually, in this verse Jay is suggesting that he’s betting against the house (Tyson), b/c if Tyson loses the fight, then the payout is larger. So by “night off” he’s saying if Tyson takes a ‘night off’, doesn’t show up for the fight (get’s beat), then he gets legal money (possibly to clean drugs) or simply legal money, period.

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