And homegirl not tryin' to be a ho
Even though she on a pole
Can she get a second chance, no

from Lupe Fiasco – Till I Get There Lyrics on Rap Genius

Meaning

Women who work as strippers are sometimes called “on the pole” because a pole is often used in their dancing.

He’s saying that they are not loose or easy women, some are doing what they can to get by. The world is too cold to give people second chances even though everyone deserves them.

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