They say life (is a gamble)
So be careful when you shake em up, shake em up, shake em up, shake em
Shake em up, shake em up, shake em up, shake em

from Big KRIT (Ft. BJ The Chicago Kid & Marvin Gaye) – Life Is a Gamble Lyrics on Rap Genius

Meaning

They say you only live once so you have to take risks, but sometimes in life the “roll of the dice” can have irreversible effects. You have to be cautious before you let go and allow the dice to decide your fate.

“Shake em up” is referring to shaking dice in your hands before you throw them.

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