I'm standing on my Monopoly board
That means I'm on top of my game

from Eminem (Ft. Lil Wayne) – No Love Lyrics on Rap Genius

Meaning

To be “on top of the game” is to be the best rapper alive

Unless you are playing Monopoly and your little brother comes running over the board and messes up your game! (in which case he’s literally on top of the game)

The specific choice of “Monopoly” as the game is well played. Eminem is in control of rap, he’s the best; he’s got a Monopoly.

he also says we came to monopolize the game in 2.0 Boys

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