I pop ack over some oxycontin

from Cam'ron (Ft. Jim Jones & Master P) – Bout It Bout It Lyrics on Rap Genius

Meaning

There don’t need to be kilos of heroin at stake: Cam will “pop” (shoot) his friend over some petty prescription painkillers

“Ack” is the hood slang for the Nation of Islam’s use of the word “acki” which means “my brother” in Arabic

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