You want them when they don’t want you, soon as they do feelings change

from Eminem – Space Bound Lyrics on Rap Genius

Meaning

Satisfaction is the death of desire!!
You want what you can’t have. The reason Em wanted the girl so badly is because he never thought he had a chance with her, he liked the thrill of pursuing her more than the girl herself. Once he got with the girl, he reached his goal and had no feelings for her.

ACCEPTED COMMENT: Referring to Em’s other songs “25 to life” and “Almost Famous”, Em might also be talking about the rap game here. He tried so hard being the number one in the game. He tried so hard to be famous. But once he’s famous, he found it’s hard to handle it.

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