Cause my stomach's in a knot
And it growls twenty-four hours a day around the tick-tock

from Redman – So Ruff Lyrics on Rap Genius

Meaning

A “knot” in your stomach could be stress, anxiety or a symptom of an actual physical problem.

Redman could be stressed at how broke he is so he resorts to robbing as a way to escape the poor life. He is hungry for money

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