Grew up, two-four, wit Pie and em
But do my dirt, 21st, wit Kyle and them

from The Roots (Ft. Beanie Sigel) – Adrenaline Lyrics on Rap Genius

Sigel, not surprisingly, grew up on Sigel Street in South Philadelphia, from which he took his rap alias. The area of it that runs through South 22nd Street and the surrounding area (including 21st Street) was still a violent area even years later. While Sigel and South 24th do not actually intersect, they are right near each other. See map here

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