I feel sicker than a cruise ship

from Lupe Fiasco – SLR 2 Lyrics on Rap Genius

Meaning

A reference to Jay’s Oceans. Large cruise ships can hold thousands of people, imagine all those people throwing up at once. Lu is saying that he’s sicker than sea sickness times a few thousand.
Lu could also be referring to norovirus outbreaks that frequently hit cruise ships. These are common stomach viruses that spread quickly through the ships given everyone’s close quarters and contact.

Following from the previous line, Lupe could be feeling sick because he hates having to admit that he wasn’t down with Jay’s album.

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