Well, he’s saying he has a handful of pills. And none of them are chasers (chasers are pills you take to prevent hangovers) meaning all the pills he’s going to take are illegal drugs.
Chasers are also, of course, typically nonalcoholic drinks used to get the taste of a drug out of the mouth. Pill poppers (or drinkers) use some other kind of drink (usually a juice for drinkers, or water for pill poppers) to get the taste of the alcohol out of your mouth (when taking shots) or to help swallow pills.
The Weeknd needs neither kind of chaser.
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