I’m on one, yeah, fuck it, I’m on one
Yeah, I said I’m on one, fuck it, I’m on one

from DJ Khaled (Ft. Drake, Lil Wayne & Rick Ross) – I'm On One Lyrics on Rap Genius

Meaning

Drake is geeked up. When somebody claims “I’m on one” he/she is going heavy with a certain drug. Drake knows that he normally doesn’t act this way. For instance in “Faded”

Damn what did I consume
Something spinning fast either me or its the room
I bet you it’s the room, because I don’t do no drugs

But tonight he’s feeling himself and says, “Fuck it.”

Eminem spat a similar line in “Drug Ballad”

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