Man, who'da knew that 3 in the morning I'd still be up
Referring to Eminem’s 3AM Song, one of the singles off of his album Relapse. He also has a line “Whoda knew the Buddha woulda do to me what it’s done” on “Buffalo Bill” off of the same album.
A handful of tylenol 3’s was the “first drugs” Eminem had ever taken, when he was suicidal — mentioned in his new book.
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