And then she get straight to that head like a fuckin excedrin

from Lil Wayne – Gettin Some Head Lyrics on Rap Genius

Meaning

This is a reference to the pain relief drug, Excedrin (naturally.) It’s very effective when used to cure headaches, and works quickly, so one could say it goes straight to the head. Much the same could be said about Hot Mouth Shelly, because she doesn’t waste time, she gets straight to that blowjob.

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