It's on my friend, on the road again, I'm traveling
Do more than 65 on 85 off in my Cadillac
I got that nigga Dre, he riding shotgun

from Outkast (Ft. Andre 3000 & Big Boi) – Ain't No Thang Lyrics on Rap Genius

Meaning

Dre is riding shotgun in Big Boi’s Cadillac as they break the 65 MPH speed limit on I-85; an interstate that bisects Atlanta from northeast to southwest. Andre later got himself in trouble for doing wayyyy more than 65 on I-75.

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