Ooooh that girl is murder (Everybody get down)
Ooooh that girl is murder (Everybody get down)

from Justin Timberlake (Ft. Jay Z) – Murder Lyrics on Rap Genius

Meaning

The song’s central metaphor is a girl whose beauty is so intense, it’s like she kills everyone around her by simply making them look dead compared with her.

“Get down” can mean getting cover from her “bullets”, but also dance or die.

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