Wine or water
Probably, Drake envisioned this girl looking at her wine and water, deciding whether to continue drinking and partying, or having some water and calling it a night (drinking lots of water after a night out is an effective technique to prevent hangovers)
Naturally, mentioning water and wine in the same sentence invokes the imagery of Jesus turning water to wine..
She could also be asking him if he’s drinking wine or water now, since she’s at home and he’s in a club.
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