Makes you want to get up and start dancin'
Even if it is Charles Manson

from Eminem – Rhyme or Reason Lyrics on Rap Genius

Meaning

Charles Milles Manson was actually a decent musician at one point. Guns and Roses covered one of his songs (titled “Look at Your Game, Girl”) and Dennis Wilson, the drummer for the Beach Boys invited him to record with the band once. But he is much more well known as one of the most twisted serial killers of all time. And since Manson allegedly brainwashed his followers, Em uses this as an example of giving the power to communicate to the wrong person.

Manson is one of Em’s most referenced serial killers, and is brought up a few times on the original Marshall Mathers LP.

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