But I bet we wouldn't probably get one block
Without me knocking your block off,

from Eminem – Rhyme or Reason Lyrics on Rap Genius

Meaning

Wordplay here: Em claims that he and his father wouldn’t be able to walk a city block (roughly 600 ft) before Em knocked him out (knocking one’s block off). He still clearly hasn’t forgiven him, and that’s why a situation like this will never happen.

It also echoes back to these lines from Sing For the Moment:

He’s a problem child, what bothers him all comes out
When he talks about his fucking dad walking out
Cos he hates him so bad that he blocks him out
If he ever saw him again he’d probably knock him out

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